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EpinephrineInjection, USP

  • FDA-approved
  • Sulfite and preservative-free

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  Pack NDC# Strength Supplied As Shelf Pack Vial Opening Size Product Info Availability

1 mg/mL

Supplied As:

1 mL single-dose ampule

NDC#: 0517-1171-10

1 mg/mL

1 mL single-dose ampule

10 N/A Out of Stock
  • Shelf Pack 10
  • Availability Out of Stock

Wholesaler Numbers

  • ABC 10276567
  • Cardinal 5824164
  • McKesson 2674430
  • Morris & Dickson 251751

Case Information

  • Unit of Sale NDC 0517-1171-10
  • Order Size 10
  • Case Size 80
  • Case Per Tier -

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For intramuscular, subcutaneous, and intravenous use.
Do not inject into buttock, digits, hands, or feet.


Emergency treatment of allergic reactions (Type I), including anaphylaxis, which may result from insect stings or bites, foods, drugs, sera, diagnostic testing substances and other allergens, as well as idiopathic anaphylaxis or exercise-induced anaphylaxis.

Hypotension associated with Septic Shock
To increase mean arterial blood pressure in adult patients with hypotension associated with septic shock.


DOSAGE AND ADMINISTRATION: See Full Prescribing Information for instructions on dilution and administration of the injection.


Incorrect Locations of Injection for Anaphylaxis
Do not administer repeated injections of epinephrine at the same site, as the resulting vasoconstriction may cause tissue necrosis.

Do not inject into buttock, digits, hands, or feet.

Extravasation and Tissue Necrosis with Intravenous Infusion: Avoid extravasation into tissues, which can cause local necrosis. When epinephrine is administered intravenously, check the infusion site frequently.

May aggravate angina pectoris or produce ventricular arrhythmias.

Serious Infections at the Injection Site: Rare cases of serious skin and soft tissue infections, including necrotizing fasciitis and myonecrosis have been reported.

Hypertension: Because individual response to epinephrine may vary significantly, monitor blood pressure frequently and titrate to avoid excessive increases in blood pressure. Patients receiving monoamine oxidase inhibitors or antidepressants of the triptyline or imipramine types may experience severe, prolonged hypertension.

Pulmonary Edema: Epinephrine increases cardiac output and causes peripheral vasoconstriction, which may result in pulmonary edema.

Renal Impairment: Epinephrine constricts renal blood vessels, which may result in oliguria or renal impairment.

Cardiac Arrhythmias and Ischemia: Epinephrine may induce cardiac arrhythmias and myocardial ischemia, especially patients suffering from coronary artery disease, or cardiomyopathy.

Allergic Reactions Associated with Sulfite -This product does not contain sodium bisulfite.

ADVERSE REACTIONS: Common adverse reactions to systemically administered epinephrine include, but are not limited to, anxiety, apprehensiveness, restlessness, tremor, weakness, dizziness, sweating, palpitations, pallor, nausea and vomiting, headache, and respiratory difficulties. These symptoms occur in some persons receiving therapeutic doses of epinephrine, but are more likely to occur in patients with heart disease, hypertension, or hyperthyroidism.

Patients with Parkinson’s disease may experience psychomotor agitation or a temporary worsening of symptoms.

Diabetic patients may experience transient increases in blood sugar.

Elderly patients and pregnant women may be at greater risk of developing adverse reactions when epinephrine is administered parenterally.

Risk Summary: May cause fetal harm.

Labor or Delivery: There are risks to the mother and fetus associated with epinephrine use during labor or delivery. Avoid epinephrine during the second stage of labor. Although epinephrine may improve maternal hypotension associated with septic shock and anaphylaxis, it may result in uterine vasoconstriction, decreased uterine blood flow, and fetal anoxia.

Risk Summary: There is no information regarding the presence of epinephrine in human milk or the effects of epinephrine on the breastfed infant or on milk production.

Pediatric Use
Reported clinical experience with the use of epinephrine suggests that the adverse reactions seen in children are similar in nature and extent to those both expected and reported in adults.

Safety and effectiveness of epinephrine in pediatric patients with septic shock have not been established.

Geriatric Use
In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

Overdosage of epinephrine may produce extremely elevated arterial pressure, which may result in cerebrovascular hemorrhage, particularly in elderly patients. Overdosage may also result in pulmonary edema, transient bradycardia followed by tachycardia and these may be accompanied by potentially fatal cardiac arrhythmias. Subsidence of the ventricular effects may be followed by atrial tachycardia and occasionally by atrioventricular block. Myocardial ischemia and infarction, cardiomyopathy, extreme pallor and coldness of the skin, metabolic acidosis due to elevated blood lactic acid levels, and renal insufficiency have also been reported.

For additional Safety Information, please see Full Prescribing Information.

You are encouraged to report Adverse Drug Events (ADEs) to American Regent Inc. at 1.800.734.9236
or to the FDA by visiting or calling 1.800.FDA.1088.